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Abstract

Thrombophilia and anticoagulation in pregnancy

Pregnancy is regarded as an acquired state of »thrombophilia « or hypercoagulation due to the impact of pregnancy hormones with a consecutive significant change in coagulation factors, the dilatation of maternal vessels and the increased venous stasis. In industrialized countries additional aspects such as a rising rate of overweight and obese women, the increased maternal age at pregnancy and a rising percentage of Caesarean sections contributes further to the risk of pregnancy associated thromboembolic disorders.Thus,pregnancy and Puerperium are considered to be the period of highest risk for thromboembolic diseases, not only in the presence of other hereditary or acquired thrombophilic disorders.The latter have furthermore been identified as risk factors for pregnancy complications such as recurrent abortions, late abortions,preeclampsia, intrauterine growth restriction and intrauterine fetal death.Thus, risk-adapted strategies for prevention and treatment of maternal thromboembolism during pregnancy and of fetal complications are mandatory.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2010; 6(1): 30-42

Keywords
Thromboembolism, pregnancy, thrombophilia,hypercoagulation, fetal complications

Michael K. Bohlmann
Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum
Schleswig-Holstein - Campus Lübeck, Lübeck

Reviewer:Volker Thäle, Halle/Saale
und Ekkehard Schleussner, Jena

Bohlmann M. K. Thrombophilie ... Gynakol Geburtsmed Gynakol Endokrinol 2010; 6(1):30-42 publiziert 31.03.10 www.akademos.de/gyn ©akademos Wissenschaftsverlag 2010 ISSN 1614-8533