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Abstract

Therapy of estrogen deficiency disorders in patients with breast cancer

Menopausal symptoms such as hot flashes, disturbances, decreased libido and vaginal atrophy are seen in about 75 % of all menopausal patients. With a median age of over 62 years many patients with breast cancer suffer from these symptoms. Also premenopausal patients with breast cancer may suffer from the same symptoms during chemotherapy or an adjuvant endocrine therapy. These menopausal symptoms often reduce quality of life in breast cancer patients. Low serum levels of estrogen may lead to osteopenia or osteoporosis in postmenopausal women. So far a hormone therapy (HT) with estrogen in combination with progestins is contraindicated in patients with breast cancer. The following review focuses at the recent studies of HT in breast cancer and alternative strategies to manage menopausal symptoms in breast cancer patients.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2011; 7(2): 100–112

Keywords
Hormone therapy, breast cancer, menopausal symptoms, quality of life

Maximilian Mögele, Stefan Buchholz, Stephan Seitz,
Olaf Ortmann
Klinik für Frauenheilkunde und Geburtshilfe der Universität
Regensburg am Caritas Krankenhaus St. Josef, Regensburg
Reviewer: Alfred Mueck, Tübingen
und Petra Stute, Bern, Schweiz

Mögele M. Therapie ... Gynakol Geburtsmed Gynakol Endokrinol 2011; 7(2): 100–112 publiziert 31.07.11 www.akademos.de/gyn ©akademos Wissenschaftsverlag 2011 ISSN 1614-8533