In cooperation with

Abstract

Breast cancer: screening, diagnosis and therapy – part 2

For a long period, breast cancer was considered a loco regional disease spreading via lymph nodes. As a result, radical mastectomy was introduced as the method of treatment at the end of the 19th century by Halsted in the United States and Rotter in Germany. This surgical procedure was state of the art until the 70s. Only then evidence started to emerge that systemic treatment might have an impact on the prognosis of patients with breast cancer. The findings resulted in a shift of paradigm: from a radical surgical to a breast-conserving approach combined with radiation as locoregional treatment. Furthermore, nearly all patients receive now an adjuvant systemic treatment. Depending on the feature of the tumor and the morbidity of the patient this adjuvant systemic treatment consists of chemotherapy, a targeted therapy and/or an endocrine therapy. Prolongation of progression-free survival and overall survival are the vital aims of this approach.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2014; 10(1): 76–87

Keywords
Breast cancer, adjuvant therapy, systemic therapy, chemotherapy, endocrine treatment

Susanne Briest1, Anke Kleine-Tebbe2
1 Universitätsklinikum Leipzig, Brustzentrum, Leipzig
2 DRK Kliniken Berlin | Köpenick, Berlin
Reviewer: Constanze Harms, Berlin,
und Volkmar Müller, Hamburg

Briest S. Mammakarzinom ... Gynakol Geburtsmed Gynakol Endokrinol 2014; 10(1): 76–87 publiziert 31.03.2014 www.akademos.de/gyn ©akademos Wissenschaftsverlag 2014 ISSN 1614-8533