In cooperation with

Abstract

Progestogens – classification und pharmacology

Besides the natural progestogen, progesterone, there are different classes of progestogens, such as the pregnanes dydrogesterone and medrogestone, 17a-hydroxyprogesterone derivatives (chlormadinone acetate, cyproterone acetate, medroxyprogesterone acetate, megestrol acetate), 19-Norprogesterone derivatives (nomegestrol, demegestone, promegestone, trimegestone, nesterone), 19-nortestosterone derivatives (norethisterone, lynestrenol, levonorgestrel, desogestrel, gestodene, norgestimate, dienogest) and a spirolactone derivative (drospirenone). Some of the synthetic progestogens are prodrugs, which need to be metabolized to become clinically active compounds. Besides the progestogenic effect, which is common for all progestogens, there is a wide range of biological, partial effects, which are different for the various progestogens and has to taken into account, when medical treatment is to be considered and optimal clinical effects to be obtained.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2015; 11(3): 192–207

Keywords
Progesterone, progestogens, classification, biological effects, pharmacology

Adolf E. Schindler
Institut für Medizinische Forschung und Fortbildung, Essen
Reviewer: Dolores Foth, Köln,
und Alfred O. Mueck, Tübingen

Schindler A. E. Gestagene … Gynakol Geburtsmed Gynakol Endokrinol 2015; 11(3): 192–207 publiziert 30.11.2015 www.akademos.de/gyn ©akademos Wissenschaftsverlag 2015 ISSN 1614-8533