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Abstract

Antenatal RDS prophylaxis

Over 40 years ago, Liggins and Howie described as first the administration of antenatal glucocorticoids to mothers in case of imminent premature birth to induce the acceleration of lung maturation, and thus to reduce the mortality and morbidity due to a reduction of respiratory disorders. With their initial investigations, they laid a milestone in perinatal medicine. The effectiveness of antenatal glucocorticoid treatment for the induction of lung maturation and the improvement of neonatal morbidity and mortality was proven impressively in several studies and meta-analyses. The choice of the glucocorticoid, the exact dosage and the interval, the question of a repetition and thus the increase in the total dose when the threat of premature birth persists, the use in twins or IUGR fetuses is still a subject of discussion and will hereinafter be discussed.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2016; 12(1): 36–55

Keywords
Glucocorticoid, betamethasone, dexamethasone, lung maturation, preterm birth

Thorsten Braun
Klinik für Geburtsmedizin, Charité – Universitätsmedizin Berlin,
Campus Virchow-Klinikum, Berlin
Reviewer: Matthias Heckmann, Greifswald,
und Manuela Tavares de Sousa, Hamburg

Braun T. Antenatale … Gynakol Geburtsmed Gynakol Endokrinol 2016; 12(1): 36–55 publiziert 31.3.2016 www.akademos.de/gyn ©akademos Wissenschaftsverlag 2016 ISSN 1614-8533