In cooperation with


"Elderly patients" in gynecologic oncology

About 60 % of all death above the age of 65 years are caused by malignancies, underlining the importance of geriatric oncology. In breast or ovarian cancer or instance, about half of the patients are older than 65 years.There is limited data about elderly cancer patients in the literature, as many trials excluded patients older than 65 years in the past and many physicians did not offer study participation to elderly patients. Several studies could show that elderly patients receive significantly less adequate surgical and adjuvant cancer treatment compared to younger patients. This observation could partially explain the less favourable prognosis of elderly patients with gynecologic malignancies. The aim of this review is to discuss the clinical management of elderly patients with gynecologic malignancies under special consideration of pharmacokinetic and pharmacodynamic aspects.

Jalid Sehouli1, Sven Mahner2, Edeltraut Garbe3,
Gülten Oskay-Oezcelik1
1 Klinik für Frauenheilkunde und Geburtshilfe,Campus Virchow-
Klinikum,Charité - Universitätsmedizin Berlin
2 Klinik und Poliklinik für Gynäkologie, Universitätsklinikum
3 Institut für Klinische Pharmakologie,Campus Mitte,
Charité - Universitätsmedizin Berlin
Reviewer: Oumar Camara, Jena
und Beatrix Schuback, Doberlug-Kirchhain

Sehouli J. Die "ältere ... Gynakol Geburtsmed Gynakol Endokrinol 2008;4(3):264-276 publiziert 30.11.08 ©akademos Wissenschaftsverlag 2008 ISSN 1614-8533