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Anti-mullerian hormone: reliable marker of ovarian reserve?

Anti-mullerian hormone (AMH) is mainly secreted by early antral follicles. It reflects the cohort of follicles which are principally ready for final gonadotrophic dependent maturation. Initially, AMH was supposed to be very stable under most circumstances and therefore a reliable marker of ovarian reserve. Even an association between AMH concentrations and oocyte quality was mentioned. In between, it was demonstrated that AMH concentrations vary during the menstrual cycle. With specific hormone therapies AMH concentrations can be manipulated. There is no linear correlation between AMH and oocyte quality or chances for pregnancies. AMH helps to determine the actual follicular reserve. It is useful to estimate gonadotropin dosage for ovarian stimulation to avoid treatment failures (i. e. low response, ovarian hyperstimulation syndrome).

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2011; 7(2): 114–121

Anti-mullerian hormone, marker, ovarian reserve, FSH, fertility

Joseph Neulen
Frauenklinik für Gynäkologische Endokrinologie und
Reproduktionsmedizin, RWTH Aachen, Aachen
Reviewer: Sören von Otte, Kiel
und Frank Chen, Berlin

Neulen J. Anti-Müller ... Gynakol Geburtsmed Gynakol Endokrinol 2011; 7(2): 114–121 publiziert 31.07.11 ©akademos Wissenschaftsverlag 2011 ISSN 1614-8533