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Hormonal replacement therapy in premature ovarian insufficiency

About 1 % of women are affected by spontaneous primary ovarian insufficiency (POI), cessation of ovarian function before age 40. In many cases the underlying pathogenic mechanism remains unknown. In the absence of hormonal replacement therapy (HT), women with POI might be at an increased risk for osteoporosis, cardiovascular disease as well as neurodegenerative diseases including dementia. The diagnosis POI may have a very negative impact on a women's well-being and quality of life. POI women may be affected by depression, anxiety and female sexual dysfunction. HT may reduce these risks but the evidence for this is limited. Nevertheless HT is generally recommended at least until the average age of menopause. Testosterone treatment in addition to conventional hormonal replacement therapy should be taken into account in women with premature ovarian insufficiency and female sexual dysfunction.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2012; 8(1): 16-24

Primary ovarian insufficiency, hormonal replacement therapy, testosterone treatment

Anneliese Schwenkhagen
Praxis für Gynäkologische Endokrinologie Schaudig &
Schwenkhagen, HORMONE HAMBURG, Hamburg
Reviewer: Katharina Hancke, Ulm
und Christian De Geyter, Basel

Schwenkhagen A. Hormonersatz ... Gynakol Geburtsmed Gynakol Endokrinol 2012; 8(1): 16-24 publiziert 31.03.2012 ©akademos Wissenschaftsverlag 2012 ISSN 1614-8533