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Biomarkers for the diagnosis of preterm delivery

Preterm delivery (PTD) less than 37 gestational weeks is the leading cause of perinatal morbidity and mortality. Spontaneous preterm birth accounts for up to 75% of all preterm births. Attempts to predict preterm birth have been not as successful as hoped and rates of PTD have not improved in recent years. PTD is initiated by a myriad of mechanisms, such as inflammation, uterine overdistension, uteroplacental hemorrhage and other immunologic and non-immunologic processes converging into an increased uterine contractility, cervical ripening, and decidual activation. Research has been focused on detection and prediction of PTD to distinguish between patients who will deliver prematurely and those who don?t. The following article will present a summary on the current literature on mainly used biochemical markers in singleton pregnancies with threatened preterm labor obtained from maternal blood, saliva or cervicovaginal fluids for predicting spontaneous preterm birth.

CME Prakt Fortbild Gynakol Geburtsmed Gynakol Endokrinol 2016; 12(1): 56–71

Preterm birth, biochemical markers, cytokines, fFN, pAMG-1, phIGFBP

Elisabeth von Tucher
Klinik für Geburtsmedizin, Charité – Universitätsmedizin Berlin,
Campus Virchow-Klinikum, Berlin
Reviewer: Richard Berger, Neuwied,
und Christian Egarter, Wien

von Tucher E. Biomarker … Gynakol Geburtsmed Gynakol Endokrinol 2016; 12(1): 56–71 publiziert 31.3.2016 ©akademos Wissenschaftsverlag 2016 ISSN 1614-8533